Cover Feature: Catalytic Desymmetrization of 1,3‐Difluoropropan‐2‐ols via C−F Bond Activation Using a Phosphazene Base Affords Monofluoromethyl‐Substituted Epoxides (Asian J. Org. Chem. 5/2019)
نویسندگان
چکیده
منابع مشابه
Organocatalyzed enantioselective desymmetrization of aziridines and epoxides
Enantioselective desymmetrization of meso-aziridines and meso-epoxides with various nucleophiles by organocatalysis has emerged as a cutting-edge approach in recent years. This review summarizes the origin and recent developments of enantioselective desymmetrization of meso-aziridines and meso-epoxides in the presence of organocatalysts.
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We report a desymmetrization of cyclohexadienones by intramolecular conjugate addition of a tethered dithiane nucleophile. Mild reaction conditions allow the formation of diversely functionalized fused bicyclic lactones. The products participate in facially selective additions from the convex surface, leading to allylic alcohol derivatives.
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CONSPECTUS: Vicinal diamines are important structural motifs present in various biologically and chemically significant molecules. Direct diamination of olefins provides an effective approach to this class of compounds. Unlike well-established oxidation processes such as epoxidation, dihydroxylation, and aminohydroxylation, direct diamination of olefins had remained a long-standing challenge an...
متن کاملPhosphazene base-promoted functionalization of aryltrimethylsilanes.
The activation of Ar-Si bonds in aryltrimethylsilane was investigated using a catalytic amount of t-Bu-P4 base and selective functionalizations of aryltrimethylsilanes in the absence of strong electron withdrawing groups on the aromatic rings were accomplished.
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Metal-free cucurbit[7]uril (CB7) solid-state assemblies promote acid-catalysed alcoholysis of aliphatic and aromatic epoxides under mild conditions to give β-alkoxy alcohols, which are important intermediates for the synthesis of a vast range of compounds such as bioactive pharmaceuticals. The catalytic process is heterogeneous and the catalyst can be reused in consecutive runs without any reac...
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ژورنال
عنوان ژورنال: Asian Journal of Organic Chemistry
سال: 2019
ISSN: 2193-5807,2193-5815
DOI: 10.1002/ajoc.201900245